Research

   TRANSLATIONAL BIOMEDICINE                

Along with collaborators in the Interreg Biomat-on-Chip Consortium, we are developing organoids for in-vitro lab-on-a-chip biomaterials devices. We are also developing disease models for assessing the response of such organoids to industry-relevant biomaterials. 

 

 

Neural Tube and Paraxial Mesoderm 
organoids

Patterning events in development can be modelled with organoid model systems. We have shown that neural tube dorso-ventral patterning can be recapitulated from mouse embryonic stem cells in synthetic 3D matrices. We are now transposing these findings to human neural tube contructs in order to understand how pattern scaling and symmetry-breaking is generated, and what this tells us about the inherent self-organization properties of stem cells.

 

MicroDEVICES and active organoid MANIPULATION

We develop microfluidic devices to generate morphogen gradients and impose dynamic traction forces in 3D to understand the role of biomolecule transport and active cellular remodeling in scaling, pattern formation and morphogenesis. 

 

3D cellular Microarrays

We use a combinatorial synthetic materials platform based on liquid handling robotics and automated imaging to understand the role of the extracellular microenvironment in specifying organoid fate and patterning.